Scientists have identified a chemical in the brain that can be blocked to boost the learning of music and language in adults. Learning language or music is usually a breeze for children, but the capacity declines dramatically with age. Scientists from St Jude Children’s Research Hospital in the US showed that limiting the supply or the function of the neuromodulator adenosine in a brain structure called the auditory thalamus preserved the ability of adult mice to learn from passive exposure to sound much as young children learn from the soundscape of their world. “By disrupting adenosine signaling in the auditory thalamus, w “By disrupting adenosine signaling in the auditory thalamus, we have extended the window for auditory learning for the longest period yet reported, well into adulthood and far beyond the usual critical period in mice,” said Stanislav Zakharenko, a member of the St Jude Department of Developmental Neurobiology.”These results offer a promising strategy to extend the same window in humans to acquire language or musical ability by restoring plasticity in critical regions of the brain, possibly by developing drugs that selectively block adenosine activity,” said Zakharenko. The auditory thalamus is the brain’s relay station where sound is collected and sent to the auditory cortex for processing. The auditory thalamus and cortex rely on the neurotransmitter glutamate to communicate. Adenosine was known to reduce glutamate levels by inhibiting this neurotransmitter’s release.nThe study published in the journal Science, linked adenosine inhibition to reduced brain plasticity and the end of efficient auditory learning. Researchers used a variety of methods to demonstrate that reducing adenosine or blocking the A1 adenosine receptor that is essential to the chemical messenger’s function changed how adult mice responded to sound. Much as young children pick up language simply by hearing it spoken, researchers showed that when adenosine was reduced or the A1 receptor blocked in the auditory thalamus, adult mice passively exposed to a tone responded to the same tone stronger when it was played weeks or months later.