Scientists have built a DNA-analysing smartphone attachment that is a fraction of the cost of lab-based kit. The creators of the phone-powered pathology microscope believe it could

be mass produced for less than $500 (£406) a unit. They say it could help doctors treat cancer, tuberculosis and other diseases more effectively than is sometimes possible in the developing world. But a UK firm says it is developing a more advanced and cheaper alternative. Details of the peer-reviewed project are published in the journal Nature Communications. The prototype microscope attachment was 3D-printed and developed as a joint effort by the University of California, Stockholm University and Uppsala University. One of the researchers involved said the tech could help medics examine tissue samples without having to send them to what might be a remote laboratory. “It can use the information that is carried in our DNA to make diagnoses,” Prof Mats Nilsson told the BBC. “There are two main areas where this is done today.”In cancer, where certain mutations in tumours confer resistance to drugs, it can be used to prescribe the right treatments. “And in infectious diagnostics, it’s the fastest way to work out if an infection is viral or bacterial, and, if it’s bacteria, to figure out if it carries antibiotic resistant genes or not.” To use the device, a sample of the patient’s tissue is put in a container and then placed under a special lens attached to the smartphone’s own camera. Two laser diodes and a white LED then beam light into the sample in a pre-set sequence, and the resulting images are fed into an algorithm for analysis. A Nokia Lumia 1020 was used in the experiment – a model known for its picture quality when it was released, in 2013. But Prof Nilsson said the equipment could be adapted for use with newer smartphones. And he suggested that an immediate use could be to treat tuberculosis in India and elsewhere. “Currently it’s a trial and error thing – they start with the first-line drugs even if one knows that only 50% of the patients will respond, since resistance is so widespread,” he said. “Then it can take three months to follow up, in which the patient can spread the disease. “So, one should stop doing that and treat patients with the right antibiotics at the time of diagnosis, and the only way to figure that out in the short-term is an affordable and simple DNA test.” The charity Cancer Research UK suggested the tech could also have use in developed nations.

No Comments

Leave a Comment