Republican Sen. Susan Collins’ decision to oppose the GOP push to repeal President Barack Obama’s health care overhaul leaves the effort all but dead, with even party leaders conceding that their prospects are dismal. “It’s going to be a heavy lift,” South Dakota Sen. John Thune, the No. 3 GOP Senate leader, said Monday, after Collins joined a small but pivotal cluster of Republicans saying they’re against the measure. He called the prospects “bleak.” “We don’t have the support for it,” said Sen. Orrin Hatch, R-Utah. The collapse marks a replay of the embarrassing loss President Donald Trump and party leaders suffered in July, when the Senate rejected three attempts to pass legislation erasing Obama’s 2010 statute. The GOP has made promises to scrap the law a high-profile vow for years, and its failure to deliver despite controlling the White House and Congress has infuriated conservatives whose votes Republican candidates need. To resuscitate their push, Republicans would need to change opposing senators’ minds, which they’ve tried unsuccessfully to do for months. Collins told reporters that she made her decision despite a phone call from Trump, who’s been futilely trying to press unhappy GOP senators to back the measure. Barring a reversal, Senate Majority Leader Mitch McConnell, R-Ky., must decide whether to hold a roll call at all. Three GOP “no” votes would doom the bill. GOP Sens. John McCain of Arizona, Rand Paul of Kentucky and Texas’ Ted Cruz have said they oppose the measure, though Cruz aides said he was seeking changes that would let him vote yes. Sen. Lisa Murkowski, R-Alaska, remains undecided. Murkowski, who voted against the failed GOP bills in July, has said she’s analyzing the measure’s impact on her state, where medical costs are high. This was the last week Republicans had any chance of prevailing with their narrow 52-48 Senate margin. Next Sunday, protections expire against a Democratic filibuster, bill-killing delays that Republicans lack the votes to overcome. Republicans had pinned their last hopes on a measure by GOP Sens. Bill Cassidy of Louisiana and South Carolina’s Lindsey Graham. It would end Obama’s Medicaid expansion and subsidies for consumers and ship the money — $1.2 trillion through 2026 — to states to use on health services with few constraints. Collins announced her decision shortly after the nonpartisan Congressional Budget Office said “millions” of Americans would lose coverage under the bill and projected it would impose $1 trillion in Medicaid cuts through 2026. The Maine moderate said in a statement that the legislation would make “devastating” cuts in the Medicaid program for poor and disabled people, drive up premiums for millions and weaken protections Obama’s law gives people with pre-existing medical conditions. She said the legislation is “deeply flawed,” despite eleventh-hour changes its sponsors have made in search of support. Desperate to win over reluctant senators, GOP leaders revised the measure several times, adding money late Sunday for Alaska, Arizona, Maine, Kentucky and Texas in a clear pitch for Republican holdouts. They also gave states the ability — without federal permission — to permit insurers to charge people with serious illnesses higher premiums and to sell low-premium policies with big coverage gaps and high deductibles. Loud protesters forced the Senate Finance Committee to briefly delay the chamber’s first and only hearing on the charged issue. Police lugged some demonstrators out of the hearing room and trundled out others in wheelchairs as scores chanted, “No cuts to Medicaid, save our liberty.” On Monday, Trump took on McCain, who’d returned to the Senate after a brain cancer diagnosis in July to cast the key vote that wrecked this summer’s effort. Trump called that “a tremendous slap in the face of the Republican Party” in a call to the “Rick & Bubba Show,” an Alabama-based talk radio program. Cassidy and Graham defended their bill before the Finance committee.